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Polymorphismen

Wir untersuchen Ihre Zelllinien auf folgende Polymorphismen:

Adrenergic receptor-1 (ADRB1 G16R)
Adrenergic receptor-2 (ADRB2 Q27E)
Alpha-Actinin (ACTN3 )
Angiotensin Converting Enzyme (ACE I/D)
Apolipoprotein B (APOB, XbaI-Mutation)
Apolipoprotein B (APOB 3500)
Apolipoprotein E (APOE ε2, ε3, ε4 Allel)
CD24 (CD24 1527 TG/del)
Collagen Typ 11 (COL1A1 SP1 G/T)
Catechol-O-Methyltransferase (COMT V158M)
Cytotoxic T-Lymphocyte Antigen 4 (CTLA4 G49A)
Faktor II Prothrombin ( FII G20210A)
Faktor V Leiden (APC-Resistenz) (FV G1691A)
Fatty acid-binding protein (FABP2 )
Glutathion-S-Transferase M 1 (GSTM1 Deletion)
Glutathion-S-Transferase M 3 (GSTM3
Glutathion-S-Transferase P 1 (GSTP1)
Glutathion-S-Transferase T 1 (GSTT1 Deletion)
Glutathion-Peroxidase 1 (GPX1 G599T)
Interleukin-1 alpha (IL-1A C-899T)
Interleukin-1 beta (IL-1B (-511))
Interleukin-1 beta (IL-1B +3953)
Interleukin-1 Rezeptor-Antagonist (IL-1RN )
Interleukin-4 (IL-4 C-589T)
Interleukin-6 (IL-6 G-174C)
Interleukin 10 (IL10 G-1082A)
Katalase (CAT A-89T und C-262T)
Laktase (LAC T-13910C)
LDL receptor-related protein (LRP1 C766T)
Methylentetrahydrofolat-Reduktase (MTHFR C677T und A1298C)
mikrosomale Epoxidhydrolase (EPHX1 Y113H)
Multiple Drug Resistance 1 (MDR1 C3435T)
N-Acetyltransferase 2 (NAT2 C481T, G590A, G857A)
Östrogen-Rezeptor (ER XbaI, PvuII)
Plasminogenaktivator-Inhibitor (PAI-1 675 4G/5G)
Peroxisome proliferator-activated receptor gamma (PPARG Pro12Ala)
Superoxiddismutase 1 (SOD1 A35C)
Superoxiddismutase 2 –Leadersequenz (SOD2 A16V)
Superoxiddismutase 2 T175C (SOD2 T175C)
Superoxiddismutase 3 (SOD3 R213G)
Sulfotransferase 1A1 (SULT1A1 G638A)
Tumor-Nekrosefaktor alpha (TNFA G-308A)
Vitamin-D3-Rezeptor (VDR3 TaqI)
Vitamin-D3-Rezeptor (VDR3 BsmI)
Cytochrom P450 1A2 (CYP1A2 *1F)
Cytochrom P450 2A6 (CYP2A6 *2)
Cytochrom P450 2D6 (CYP2D6 *3*4)
Cytochrom P450 2C9 (CYP2C9 *2*3)
Cytochrom P450 3A4 (CYP3A4 *1B)
Cytochrom P450 2B6 (CYP2B6 *5)
Dihydropyrimidin-Dehydrogenase (DPYD*2)

Die Analysen werden mittels Real Time PCR durchgeführt. Nach Rücksprache können auch andere Polymorphismen untersucht werden.